Course No. Chem 513
Nature of Course: Theory
Group A.
Acids and Bases: Bronsted theory, acid and base solvents, measurement of solvent acidity (no methamatical derivation).Acid and Base Catalyst:Lewis acid and bases, hard and soft acids and bases, effects of structure on the strength of acids and bases. effect of medium on acid and base strength.
Effect of Structure on reactivity: Resonance and field effect, Steric effect, Hammette Equation.
Aliphatic Nucleophilic Substitution: Review of lecture (SN1, SN2, SNi mechanism with suitable examples) ,the neighboring group mechanism, the neighboring group participation by σ and π bond, non classical carbocation.
Aromatic Nucleophilic Substitution: Review Lecture, the Benzyne maechanism, the effect of substrate structure, the effect of leaving group,the effect of attacking nucleophile.
Aromatic Electrophilic Substitution: Review lecture, orientation and reactivity in mono substituted benzene ring, ipso attack.
Aliphatic Electrophilic Substitution: Review lecture, bi molecular mechanism, SE2 and SE1 mechanism with suitable examples.
Free Radical Substitution: free radical substitution mechanism, mechanism in general , neighbouring group assistance in free radical reactions, allylic halogenation.
Addition to Carbon carbon multiple bonds: Review , addition to conjugated base system and addition to cyclopropane ring.
Addition to carbon hetero multiple bonds : Mechanism and reactivity ( the Mannich raction , carbon attack by organometallic compound, the Aldol Condensation, the Reformatsky reaction, Micheal reaction, the Peterson olefination reaction, the Perkin's reaction, Darzen's glycidic ester condensation, tollen's reaction ,the Wittig reaction.
Elimination Reactions: Mechanism and orientation, review lecture, the E1 mechanism, E2 mechanism, E1cB reaction, orientation of double bonds.
GROUP B
Photochemistry: Introduction, thermal and photochemical energy, activation energy, photochemical excitation, electronic transition, Inblonski diagrams, inter system crossing, photolytic cleavage, laws of photochemistry, photochemistry of carbonyl compounds, photochemistry of Ketones, Olefins photochemistry, 
-cleavage , beta-cleavage reactions, hydrogen abstraction, Paterno Buchhi reaction, Photo dimetization, Photo reduction of Carbonyl Compounds, Photochemical oxidation, photochemical rearrangement, photo chemistry of - beta unsaturated ketones, Photochemical reactions on the atmosphere, introduction to electoro cyclic reactions and cycloaddition.......13 hrsChemistry of Heterocyclic Compounds: Reactions, synthesis and uses of oxirane, Aziridine, Thirane, imidazole, thiazole, oxazole, indoles......6hrs
Organometallic Compound: Preparation and application of organomagnesim, organoaluminium and organolithium....3 hrs
Disconnection approach or retrosynthesis analysis: Synthons and synthesis eqvalents, functional group interconversion, one group C-X disconnections, two groups C-X disconnections, retrosynthetic analysis.
Introduction to combinational chemistry: The premise of combinationatorial chemistry with example.
Green Chemistry: Introduction to microwave induced synthesis......4 hrs
Group C
Macromolecular Chemistry: Introduction to macromolecules, Macromolecule of industrial importance, Special properties of large molecule, typpes of polymerization, mechanism of chaim growth polymerization.....7Carbohydrates Disaccharides: determination in the structure of sucrose, Polysaccharides ( starch and cellulose, introduction to glycosides ( cardiac glycosides)......6
Synthesis of Small rings; 3-4 membered rings, medium sized rings (5-7)and large rings(above 8 members_, Structure elucidation and synthesis of muscone civetone.....6
Stereochemistry:
Molecular symmetry and chirality's : Introduction to symmetry, operation and symmetry elements of simple and prorper axis of symmetry, plane of symmetry, center of symmetry, alternating axis of symmetry.....2
Racemization and methods of resolution" Mechanism involving carboanions carbocations, free radical and rotation around bonds, resolution through the formation of diasteromers, correlation based on symmetric synthesis, Cram;s and Perlong's rule........7
Supra molecular Chemistry: Introduction to supra molecular chemistry, examples of supra molecular compounds,,,Crown ether and their uses, Inclusion compounds..
GROUP D
Natural Product chemistry: Introduction, Scope of Natural Products Chemistry, Selection of the plant materials, extraction procedure, phytochemical screening......Separation Technique; types of Chromatography, Basic principles and application of TLC, Column chromatography, Gas Chromatography, HPLC, Gel Chromatography and afffinity chromatography....
Spectroscopic Techniques: theory and application of IR, UV, Mass spectroscopy and C-NMR...10Hrs
Uses of Spectroscopic Techniques in structure elucidation of simple organic compounds...6
